Abstract
Background: Intrauterine growth restriction (IUGR) will increase the risk of impairment of renal function in the future. Objective: To assess renal function in infants with a history of IUGR up to 36 weeks gestation compared to infants with normal growth. Method: Laboratory examination of urine microalbumin, urine creatinine and a cystatin C blood test were done on day 7 after birth in infants with a history of IUGR and in infants with normal growth up to 36 weeks gestation and compared. Results: On day 7 after birth, mean urine microalbumin levels of IUGR and normal weight infants were 15.83 ± 31.32 mg/ml and 1.9 ± 0.97 mg/ml respectively (p 0.05). Conclusions: Mean urine albumin level, mean urine creatinine level and mean urine albumin/creatinine ratio of IUGR infants were significantly higher than those of normal weight infants. There was no significant difference between the mean cystatin C levels of IUGR infants and normal weight infants. (Keywords: Renal function of infants with IUGR, microalbumin, creatinine, cystatin C) Sri Lanka Journal of Child Health , 2017; 46 (2): 152-154
Highlights
Barker Hypothesis 1995 emphasizes the close relationship of intrauterine growth restriction (IUGR) to hypertension, coronary heart disease, diabetes mellitus and peripheral vascular disease in adulthood[1]
There was no significant difference between the mean cystatin C levels of Intrauterine growth restriction (IUGR) infants and normal weight infants
The cases were pregnant mothers whose fetuses had IUGR at 28-36 weeks gestation, while controls were pregnant mothers whose fetuses had normal weights and who were matched for gestational ages as the cases
Summary
Barker Hypothesis 1995 emphasizes the close relationship of intrauterine growth restriction (IUGR) to hypertension, coronary heart disease, diabetes mellitus and peripheral vascular disease in adulthood[1]. The World Health Organization (WHO) defines small for gestational age (SGA) as a neonatal weight of less than 2500g at term[2]. The terms IUGR and SGA are commonly used interchangeably. A more widely used definition of IUGR in the developed countries is an estimated weight less than the 10th percentile for gestational age or a weight that is less than two standard deviations below the anticipated value for the gestational age[3]. IUGR is reported to affect 1015% of pregnant women[4]. Intrauterine growth restriction (IUGR) will increase the risk of impairment of renal function in the future
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