Abstract
Objective: The objective of this study was to discover and examine the in vitro wound healing activity of selected medicinal plants against common wound infecting microorganisms.
 Methods: Ziziphus rugosa and Hemidesmus indicus plant parts were used for aqueous and solvent extract preparation, maceration technique was followed. In vitro antibiotic test has been done using disc diffusion method.
 Results: Maximum yield for aqueous extract was observed in Z. rugosa bark sample (50.6%) and minimum yield was noted in H. indicus leaf extract in (45.7%) and maximum yield in solvent extract was observed in methanol extract of Z. rugosa (37.5%) whereas minimum yield was observed in of acetone extract of leaves of Z. rugosa (25%). For all sample extracts tested, leaf extract of acetone and methanol extract of Z. rugosa and H. indicus showed the highest antibiotic zone of inhibition of 15 mm and 12 mm, whereas lowest zone of inhibition was observed in aqueous bark extract of Z. rugosa (7 mm).
 Conclusion: Crude aqueous and solvent extract of selected plant were showed that promising results have a wound healing aid, efficacy of which could be further improved by studying and practicing more advanced extraction procedure for future prospectus.
Highlights
In India, there are about 47,000 plant species and they are distributed in various vegetation zones
Bark possess strong astringent and antidiarrheal properties various works posted that this plant shows anti-inflammatory, anxiolytic, central nervous system (CNS) depressant, antifungal, cytotoxic, antibacterial, analgesic, antioxidant, and antimicrobial properties
Material The two medicinal plants Z. rugosa and H. indicus were selected for the antimicrobial study based on their literature study and their usage as home remedies for wound healing and anti-inflammatory property across various parts of Western Ghats of Uttar Kannada district of Karnataka from where they have been collected for the study
Summary
In India, there are about 47,000 plant species and they are distributed in various vegetation zones. Bark possess strong astringent and antidiarrheal properties various works posted that this plant shows anti-inflammatory, anxiolytic, central nervous system (CNS) depressant, antifungal, cytotoxic, antibacterial, analgesic, antioxidant, and antimicrobial properties. H. indicus has been used as a folk medicine for a long time and found to be an important part of Ayurvedic and Unani medicine. It is a perennial climber found in the eastern and southern parts of India [6]. It is a slender, laticiferous, and endangered shrub that is known for its immense medicinal values; for example, antivenom, antiarthritic, antimicrobial, antiulcer, antileprotic, anticancerous, hepatoprotective, immunomodulatory, wound healing property, etc. The immense medicinal values of H. indicus can be considered as a royal source of herbal medicine in India [7,8]
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