Abstract
Perforin/granzyme and Fas/Fas ligand (Fas L) pathways are two known major pathways of cytotoxic T lymphocyte (CTL)-mediated apoptosis. We clinically studied whether CTL-mediated apoptosis associated with peptic ulcer formation may occur via either or both of these two pathways. In all mucosal biopsy specimens obtained from the peptic ulcer marginal zone endoscopically with or without Helicobacter pylori infection, perforin/granzyme B and caspase 3 were expressed consistently, but FasL was not. Apoptotic changes of target cells by perforin/granzyme B were then observed via immunohistochemistry. These results suggested that the main pathway of CTL-mediated apoptosis in peptic ulcer formation was the perforin/granzyme pathway.
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