Examination of bioactivity studies of phosphate glasses doped with strontium

Abstract

Glass samples of the composition 45P2O5-xNa2O-(50-x)CaO-5SrO (x = 20, 25, 30, 35 mol%) were prepared by conventional melt quench method and were subjected to in vitro bioactivity studies by immersing in Simulated Body Fluid (SBF) solution with pH = 7.4 at 37 °C. In vitro bioactivity study of strontium doped phosphate glasses involves examining the interaction between the glass material and biological systems, such as cells or tissues. The crystalline phase, functional group analysis, surface morphology and elemental composition of the synthesised samples were evaluated using X-ray Diffraction (XRD), Fourier Transform Infrared (FTIR), Scanning Electron Microscope (SEM) and Energy Dispersive X-Ray (EDX) analyses respectively. Strontium doped phosphate glasses are a type of biomaterials that have prospective applications in the field of bone tissue engineering and regeneration. The formation of hydroxyapatite layer on the surface of glasses post immersion in SBF was confirmed by XRD and FTIR spectra. SEM micrographs revealed the formation of crystal agglomerates on the surface of glasses. EDX confirmed the presence of Ca and P ions. The fixed concentrations of phosphorus oxide and strontium oxide have been found to have an impact on the properties of the glass material, even as the amounts of sodium oxide and calcium oxide are varied. The results of these studies can yield valuable insights into the bioactivity of the glasses and their potential applications in the fields of bone tissue engineering and regeneration.