Abstract
Examination of Alzheimer‐Type Neurodegeneration in Mouse Trisomy 16 Neurons Maintained by Transplantation
Highlights
Down’s syndrome (DS, trisomy 21) results from an extra copy of human chromosome 21
Animal models would greatly aid the elucidation of processes underlying the neuropathology of DS and AD
To determine whether the trisomy 16 mouse could be a useful model for AD, we investigated whether trisomy 16 brain tissue develops AD neurodegeneration and neuropathology
Summary
Trisomy 16 Neurons Maintained by Transplantation J. Included in the phenotype of this syndrome is the development of neurofibrillary tangles and neuritic plaques that are characteristic of Alzheimer’s disease (AD) (Wisniewski KE et al, Ann Neurol 1985; 17: 278-282). Murine trisomy 16 is a proposed genetic model for DS owing to the homology between mouse chromosome 16 and human chromosome 21
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
