Abstract
Critical appraisal of vaccine approaches to control bovine mastitis. Despite their interest to combat mastitis, vaccines are few and underused, owing to limited efficacy. The mammary gland may have established with its pathogens a modus vivendi that favours the settlement of chronic subclinical infections. Reprogramming this immune response in a way that favours bacteriological cure but spares the secretory function presents a major challenge to immunologists. To improve vaccine efficacy, stress should be put on research on T lymphocyte-dependent immune defenses. In this view, improved knowledge of mammary lymphocyte populations, in association with systems vaccinology approaches, should offer new prospects for the development of efficient vaccines.
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