Exact analysis of antibody-coated silicon biological nano-sensors (SBNSs) to identify viruses and bacteria

Abstract

In this paper, the vibration analysis of a Silicon Biological Nano-sensor (SBNS) with full coverage of Myosin as biologically adsorbent layer is investigated based on modified nonlocal Euler–Bernoulli beam model. This SBNS works based on calculating the shift of resonant frequency in the presence of Myosin layer and adsorbed viruses and bacteria. For this end, the effects of surface stresses, nonlocal parameter, and rotary inertia as well as the mass and stiffness of the adsorbent layer are taken into account, which can play a major role in changing the resonant frequency and the precision of SBNSs at nano-scale. The results illustrate that the effects of adsorbent layer, surface stresses, nonlocal parameter and rotary inertia may reduce resonant frequency of SBNS, which is significant especially at nano-scale. Finally, for the purpose of verification assessment, the numerical results were compared with the results of other studies and showed complete agreement. The present study can provide helpful insights for the design and characterization of accurate biological Nano-sensors.