Exacerbation of neurofibromatosis and adverse pregnancy outcome. A case report and review of the literature

Abstract

Neurofibromatosis type 1 (NF-1) is a condition which has markedly variable clinical expressions. During pregnancy the manifestations of the disorder are exacerbated, and as a result, mild to severe maternal and fetal complications may appear. A case of neurofibromatosis affected by pregnancy is presented. The mother presented with high arterial blood pressure, renal insufficiency, and visual impairment. At the same time the baby was born with growth restriction and cerebellar haemorrhage. Altogether, NF1 is associated with increased maternal and fetal morbidity in pregnancy but not with increased maternal mortality.