Abstract
Since its discovery in December 2019, corona virus was outbreak worldwide with very rapid rate, so it described by WHO as pandemic. It associated with severe acute respiratory distress syndrome, and can enter to cells through Angiotensin Converting Enzyme 2 (ACE 2) receptor which play an important role as regulator for blood pressure. Hypertension is a potential risk factor for sever acute respiratory syndrome COVID-19, and associated with high mortality rate as shown in many epidemiological studies. Moreover, specific antihypertensive medications that infected patients were receiving are not known; only data about renin-angiotensin-aldosterone system (RAAS) are available.
Highlights
Coronavirus is a novel corona virus, or called corona virus disease COVID-19 as it appear firstly in 2019 in Wuhan, China, it is worldwide outbreak [1,2]
The entry of SARS-Cov-2 into the cells occur through Protein Binding Domain (PBD) of the Angiotensin Converting Enzyme2 (ACE2) receptor, which considered as a key hormone for blood pressure regulation
Angiotensin Converting Enzyme (ACE)-I/ and or Angiotensin Receptor Blockers (ARBs) were not associated with the increased risk of mortality or sever manifestations in patients with COVID-19 infection
Summary
Coronavirus is a novel corona virus (nCOV), or called corona virus disease COVID-19 as it appear firstly in 2019 in Wuhan, China, it is worldwide outbreak [1,2]. This virus belong to a family of positive single stranded RNA (+ssRNA) with a diameter ranging from (60-140 nm), Which can be classified as α, β, δ, and γ [3,4]. Due to the high genome similarity with SARS-CoV, (86.9%), so it is called (SARS-CoV-2) [7]
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Schedule a callMore From: Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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