Ex Vivo Characterization of the Epitope-Specific T Cell Response to Alternaria

Abstract

Specific immunotherapy for fungal allergy has seen limited success, partly due to the difficulty in obtaining fungal extract of standardized quality. Peptide immunotherapy would circumvent this problem and would limit IgE reactivity, potentially reducing the adverse events associated with SIT. Peptides could also potentially increase the efficacy of SIT, as they could be selected based on their ability to elicit the desired response.