Abstract
Oral cancers are amongst the ten most prevalent forms of cancer worldwide and one of the most common in India. Various etiological factors like smoking, alcohol, tobacco consumption have been attributed as thmain causative factors for cancer. However, studies being carried out have revealed an emerging role of various bacteria as an etiological factor in oral cancer. Different bacteria have been proposed to induce carcinogenesis either through induction of chronic inflammation or by interference, either directly or indirectly, with eukaryotic cell cycle and signaling pathways, or by metabolism of potentially carcinogenic substances like acetaldehyde causing mutagenesis. The most common bacteria implicated include P. melaninogenica, C. gingivalis, Capnocytophaga ochracea, Eubacterium saburreum, Leptotrichia buccalis and S. mitis. This paper gives a review on the various the various bacteria involved and the possible pathway for bacterial carcinogenesis.
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