Abstract
Long non-coding RNAs (lncRNAs) are a type of non-coding RNAs that act as molecular fingerprints and modulators of many pathophysiological processes, particularly in cancer. Specifically, lncRNAs can be involved in the pathogenesis and progression of brain tumors, affecting stemness/differentiation, replication, invasion, survival, DNA damage response, and chromatin dynamics. Furthermore, the aberrations in the expressions of these transcripts can promote treatment resistance, leading to tumor recurrence. The development of next-generation sequencing technologies and the creation of lncRNA-specific microarrays have boosted the study of lncRNA etiology. Cerebrospinal fluid (CSF) directly mirrors the biological fluid of biochemical processes in the brain. It can be enriched for small molecules, peptides, or proteins released by the neurons of the central nervous system (CNS) or immune cells. Therefore, strategies that identify and target CSF lncRNAs may be attractive as early diagnostic and therapeutic options. In this review, we have reviewed the studies on CSF lncRNAs in the context of brain tumor pathogenesis and progression and discuss their potential as biomarkers and therapeutic targets.
Highlights
Brain tumors refer to the primary intracranial tumors as well as the metastatic tumors in the brain with a primary lesion
We focus on the regulatory mechanism of Cerebrospinal fluid (CSF) Long non-coding RNA (lncRNA) in the pathophysiology of brain tumors and discuss its potential application as diagnostic markers and therapeutic targets
This study indicated that exosomal lncRNA played a significant role in maintaining immunosuppressive microenvironment for glioma survival and invasiveness (Yang et al, 2019)
Summary
Brain tumors refer to the primary intracranial tumors as well as the metastatic tumors in the brain with a primary lesion. CSF lncRNAs have exhibited the significance as promising biomarkers and potential targets for various brain tumors.
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