Abstract
Background: In the face of availability of newer antiepileptic drugs (AEDs) such as lamotrigine and topiramate, there is need to reassess the role of older AEDs in the treatment of juvenile myoclonic epilepsy (JME). Objectives: To explore whether lamotrigine and topiramate monotherapy or polytherapy can be effective options in the treatment of JME, and to determine whether older AEDs, suchas phenytoinandcarbamazepine, have a role in the treatment of JME. Design: A retrospective cohort study. Setting: A large academic teaching hospital. Patients:Seventy-twoconsecutiveJMEpatientstreated with valproic acid, lamotrigine, topiramate, phenytoin, or carbamazepine between April 1, 1991, and March 31, 2001.
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