Abstract
A study identifying genomic restructuring and the absence of genes as conditions permissive for the seeding of new centromeres in primates
Highlights
Evolutionary-new centromeres (ENCs) result from the seeding of a centromere at an ectopic location along the chromosome during evolution
Our analysis strongly suggested that the restructuring of the neocentromeric region is an intrinsic property of ENC progression and, the highly significant absence of genes we have observed may represent a critical pre-requisite for ENC progression and fixation in the population
We identified 31 ENCs: in Catarrhini (Old World monkeys (OWMs) and Hominoidea) and in Platyrrhini (New World monkeys (NWMs))
Summary
Evolutionary-new centromeres (ENCs) result from the seeding of a centromere at an ectopic location along the chromosome during evolution. The novel centromere rapidly acquires the complex structure typical of eukaryote centromeres. This phenomenon has played an important role in shaping primate karyotypes. The centromere is a complex structure ensuring the proper segregation of chromosomes in mitosis and meiosis It usually harbors large blocks of satellite DNA (alpha satellite in primates). In spite of their complexity, centromeres have been shown to be able to relocate along the chromosome during evolution. These novel centromeres are referred to as evolutionary-new centromeres (ENCs). The phenomenon implies the seeding of the novel centromere and the inactivation of the old one
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