Abstract
Glucokinase (GCK) plays a key role in regulating glucose homeostasis in the human body. Mammalian GCKs are particularly sensitive to the redox state of their environment and require high concentrations of reductant to maintain full catalytic activity. This observation has led to the proposal that redox regulation of mammalian GCKs may play an important role in controlling glucose metabolism in vivo. To investigate the origins of GCK’s redox sensitivity, we used ancestral sequence reconstruction to resurrect extinct proteins that existed along the vertebrate evolutionary trajectory.
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