Abstract
Population Genetics Genetic variants affecting heart development and function, such as those associated with coronary artery disease (CAD), are subject to rapid removal from the gene pool. Thus, it is expected that inherited genes related to CAD should also have positive effects. Byars et al. looked for evidence of positive selection in genes previously associated with CAD in populations across the globe. Selection signals were seen in many variants and populations, some of which were associated with the number of offspring. Thus, genetic variants that are linked to disease may also affect other traits that could affect persistence within a population. PLOS Genet. 13 , e1006328 (2017).
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