Evolution of transfer RNA and the origin of the translation system.

Abstract

The origin of the translation system is at the center of discussions about the evolution of biological systems. In this context, molecules of transfer RNA (tRNA) are highlighted due to its ability to convey the information contained in nucleic acids with the functional information contained in the proteins. Despite many characteristics shared among tRNAs in various organisms, suggesting a monophyletic origin for this group of molecules, recent discussions have proposed a polyphyletic origin for this group, thus indicating that the shared features are products of evolutionary convergence (Di Giulio, 2013). The main arguments in favor of the model for polyphyletic origin of tRNAs, is based on the theory of exons and suggests that the introns played an important role uniting mini exons or genes, which enabled that minigenes with independent origins were grouped in a single transcription unit at the start of the biological system (Di Giulio, 2012a). Genes for tRNAs have one of the most conserved introns that we know, which would represent a remnant of the process that gave rise to this molecule, being the anticodon loop initially a minigene that was attached to the other loop or hairpin that gave origin to the modern structure of tRNAs (Di Giulio, 2012b). An evidence of this model was found in Nanoarchaeum equitans, where a single tRNA is encoded by two genes that are united after the transcription (Randau et al., 2005). Podar et al. (2013), analyzed the genome of N. equitans and suggested that the organization of genes in this organism is a derived character, being consequence of a process of genomic reduction that is associated with their lifestyle (Podar et al., 2013). Thus, the tRNAs would be monophyletic, having a single ancestor that gave origin to the diversity known today, as suggested by Lacey and Staves (1990).