Abstract
The aim of the study was to evaluate the outcome of pulmonary tuberculosis with lung destruction in children. Material and methods: a retrospective, selective, analytical research was performed, which included 43 children with tuberculosis. Results: the most frequently affected were girls 25 (58.1%) and the age group between 15 and 18 years 34 (79.1%) cases.. Every second child was in tuberculous contact, 41.9% were actively detected and passively 22 (52.4%) cases, even if all patients were symptomatic. Infiltrative tuberculosis predominated, in equally proportion was extended and limited, in most patients with unilateral localization, and with dissemination. Microscopic positive were 20 (46.5%) cases, GeneXpert MTB / Rif positive 30 (69.8%) cases, including resistant in 9 (20.9%) cases. Therapeutic success was registered in 30 (69.8%) cases, 2 (4.7%) cases were lost to follow-up, continued treatment with TB RR/MDR 11 (25.6%) children. Conclusions: destructive pulmonary tuberculosis evolves with unsatisfactory therapeutic results, due to the association with epidemiological risk factors, passive detection, extensive localization and bronchogenic dissemination.
Highlights
Microscopic positive were 20 (46.5%) cases, GeneXpert MTB / Rif positive 30 (69.8%) cases, including resistant in 9 (20.9%) cases
Therapeutic success was registered in 30 (69.8%) cases, 2 (4.7%) cases were lost to follow-up, continued treatment with TB RR/MDR 11 (25.6%) children
Conclusions: destructive pulmonary tuberculosis evolves with unsatisfactory therapeutic results, due to the association with epidemiological risk factors, passive detection, extensive localization and bronchogenic dissemination
Summary
Цель исследования была оценить эволюцию туберкулеза легких с легочной деструкцией у детей. Результаты: чаще всего заболевали туберкулезом девочки 25 (58,1%) и возрастная группа от 15 до 18 лет 34 (79,1%) детей. Каждый второй ребенок находился в контакте с больным туберкулезом, активно были выявлены 41,9% и пассивно – 22 (52,4%) случая. Положительными по микроскопии были 20 (46,5%) случаев, положительными по GeneXpert MTB / Rif - 30 (69,8%) случаев, в том числе резистентными в 9 (20,9%) случаях. Терапевтический успех был зарегистрирован в 30 (69,8%) случаях, 2 (4,7%) случая были потеряны из наблюдения, продолжили лечение 11 (25,6%) детей с МЛУ ТБ. Выводы: деструктивный туберкулез легких развивается с неудовлетворительными терапевтическими результатами, что обусловлено эпидемиологическими факторами риска, пассивным выявлением, обширной локализации и бронхогенным распространением.
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