Abstract

IntroductionThe direction of the causal link between solid cancers and elevated plasma vitamin B12 (B12) remains uncertain.MethodsWe retrospectively included patients having two B12 measurements with a B12 initially ≥ 1000 ng/l and a solid cancer diagnosed between the measurements. Patients were included in the Curative or Supportive group according to their treatments.ResultsB12 changes over time differed between groups (p = 0.001): +157.4 ng/l/month in the Supportive care group versus –171.6 ng/l/month in the Curative care group.ConclusionsThe decrease of plasma B12 in cases of curative care could suggest that this B12 elevation is secondary to solid cancers.

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