Abstract
Following oral administration of ethanol to ethylic as well as non-ethylic volunteers, the entire time course of plasma acetate concentration has been observed. The curve shows a typical evolution in three phases: 1. (1) a quick ascending phase 2. (2) a steady state characterized by a mean concentraion ( C ) 3. (3) first-order decrease, characterized by its half-life ( t 1 2 ) These parameters show significant variations (increase of C , decrease of t 1 2 ) in the ethylic subjects, in comparison with the non-ethylic ones. The variation of the area under the acetate curve according to the dose of ethanol given, is linear. The comparison of such a development with the one, typically non-linear, of the area under ethanol curve previously analyzed for the same subjects, may guess the origin of the non-linearity of ethanol kinetics.
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