Abstract
BackgroundThere is a paucity of information about longitudinal patterns of IgE responses to allergenic proteins (components) from multiple sources.ObjectivesThis study sought to investigate temporal patterns of component-specific IgE responses from infancy to adolescence, and their relationship with allergic diseases.MethodsIn a population-based birth cohort, we measured IgE to 112 components at 6 follow-ups during childhood. We used a Bayesian method to discover cross-sectional sensitization patterns and their longitudinal trajectories, and we related these patterns to asthma and rhinitis in adolescence.ResultsWe identified 1 sensitization cluster at age 1, 3 at age 3, 4 at ages 5 and 8, 5 at age 11, and 6 at age 16 years. “Broad” cluster was the only cluster present at every follow-up, comprising components from multiple sources. “Dust mite” cluster formed at age 3 years and remained unchanged to adolescence. At age 3 years, a single-component “Grass” cluster emerged, which at age 5 years absorbed additional grass components and Fel d 1 to form the “Grass/cat” cluster. Two new clusters formed at age 11 years: “Cat” cluster and “PR-10/profilin” (which divided at age 16 years into “PR-10” and “Profilin”). The strongest contemporaneous associate of asthma at age 16 years was sensitization to dust mite cluster (odds ratio: 2.6; 95% CI: 1.2-6.1; P < .05), but the strongest early life predictor of subsequent asthma was sensitization to grass/cat cluster (odds ratio: 3.5; 95% CI: 1.6-7.4; P < .01).ConclusionsWe describe the architecture of the evolution of IgE responses to multiple allergen components throughout childhood, which may facilitate development of better diagnostic and prognostic biomarkers for allergic diseases.
Highlights
There is a paucity of information about longitudinal patterns of IgE responses to allergenic proteins from multiple sources
We describe the architecture of the evolution of IgE responses to multiple allergen components throughout childhood, taking into account responses to >100 allergenic molecules
By applying novel machine learning techniques to Component-resolved diagnostics house dust mite (HDM) (CRD) sensitization data from infancy to adolescence among children from a populationbased birth cohort, we identified latent structure in the diversification of the IgE responses during childhood (Figs 1 and 2)
Summary
There is a paucity of information about longitudinal patterns of IgE responses to allergenic proteins (components) from multiple sources. Objectives: This study sought to investigate temporal patterns of component-specific IgE responses from infancy to adolescence, and their relationship with allergic diseases. ‘‘Broad’’ cluster was the only cluster present at every follow-up, comprising components from multiple sources. ‘‘Dust mite’’ cluster formed at age 3 years and remained unchanged to adolescence. At age 3 years, a single-component ‘‘Grass’’ cluster emerged, which at age 5 years absorbed additional grass components and Fel d 1 to form the ‘‘Grass/cat’’ cluster. Conclusions: We describe the architecture of the evolution of IgE responses to multiple allergen components throughout childhood, which may facilitate development of better diagnostic and prognostic biomarkers for allergic diseases. Conclusions: We describe the architecture of the evolution of IgE responses to multiple allergen components throughout childhood, which may facilitate development of better diagnostic and prognostic biomarkers for allergic diseases. (J Allergy Clin Immunol 2018;142:1322-30.)
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