Abstract
Evolution of energy metabolism, stem cells and cancer stem cells: how the Warburg and Barker hypothesis might be linked.
Highlights
Cell that is the target cell for ‘initiation’?”, and “What are the underlying molecular mechanisms for each phase of carcinogenesis?” With the discovery of cancer- initiating cells within a tumor, the concept of “cancer stem cells” has been generated
There is an alterative interpretation of the origin of these “induced pluripotent stem cells” (iPS)” cells, namely, they were selected adult stem cells in those primary cultures [9]
The isolation of “MUSE” cells from normal human skin has demonstrated that these rare cells in the skin are the “target cells” for the socalled “iPS” cells [14]
Summary
Cell that is the target cell for ‘initiation’?”, and “What are the underlying molecular mechanisms for each phase of carcinogenesis?” With the discovery of cancer- initiating cells within a tumor, the concept of “cancer stem cells” has been generated. Dramatic demonstration has shown that only normal human breast stem cells could be efficiently blocked from “mortalization” and neoplastically-transformed.
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