Abstract
e14146 Background: The presence of baseline ≥ 3 (CTCs) in 7.5 mL of blood is predictive of a poor outcome in advanced colorectal cancer (JCO, 26;19: 3213-3221, 2008). The aim of this prospectively. study was to quantified CTCs performance during neoadjuvant treatment and before/after radical surgery in pts with L-CRC. Methods: From February 2009 to October 2010, 18 pts with L-CRC were included. Median age was 61 years old (48-79), 55.6% men. K-Ras status was: 54% wild-type; 46% mutated. 7.5 mL of blood were drawn in CellSave tubes. CTCs were isolated and enumerated at baseline, before and just performed radical liver surgery. CTCs were immunomagnetically separated and fluorescently labeled using the CellSearch System (Veridex/Immunicon Corp.). Results: Baseline determination was < 3 CTCs in 72.2 % of pts, and increased to 77.8% just before liver surgery. A slight decreased in pts with < 3 CTCs was observed after liver surgery (70.6%). Conclusions: Unlike the published data of CTCs before/after liver surgery in systemic circulation (JCO, 20;27:6160-5, 2009), our study shown a modest increased in CTCs after liver metastases resection of advanced CRC. Role of radical metastases surgery in kinetic of CTCs must be analyzed in future studies.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
