Abstract
Nucleotide modifications are important for the proper folding and the stability of most structured RNA molecules. The ribosomal RNAs of Archaea and Eukaryotes contain large numbers of 2′-O-methyl and pseudouridine modifications. A family of small RNAs, the C/D box s(no)RNAs, utilizes base complementarity with target RNAs to guide methyltransferase activity. Thus, the guide sequences of C/D box sRNAs determine the scope of 2′-O-methylations within archaeal and eukaryotic organisms. In this chapter, we describe the general architecture and functionality of C/D box sRNAs with a focus on the accelerated evolution of their guide sequences. The plasticity of C/D box sRNA biogenesis allows for the evolution of novel guide RNA sequence pairs and permits adjustments of the cellular modification landscape.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
