Abstract
Endothelial progenitor cell (EPC) transplantation therapy is a promising method in the field of regenerative therapy. EPCs, which were identified in adult peripheral blood, have the ability to differentiate into endothelial cells (ECs). Because of the potential for EPCs to promote tissue regeneration, transplantation of autologous EPCs is now recognized as a novel therapeutic option for revascularization and blood vessel repair in ischemic diseases, diabetic refractory limb ulcers, and other conditions. However, aging and various conditions and disease states, such as diabetes and arteriosclerosis, are associated with reduced numbers and dysfunction of EPCs, which may result in decreased efficacy of autologous therapies. Therefore, in order to achieve better clinical outcomes in the treatment of a variety of conditions and diseases, further advances in regenerative therapies utilizing EPCs are required. In this review, we describe the potential roles of EPCs in vasculogenesis and tissue regeneration. We focus on the development of EPC-based treatments and provide insights into the future of regenerative therapies utilizing EPCs for tailor-made medicine.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.