Abstract
Human endogenous retroviral element S-family (HERV-S) has been present within
 the human genome as well as various closely related primates. The expression
 pattern, copy number, chromosomal locations of the proviral element have been
 extensively studied. Here, we analyse the pol fragment of the HERV-S in human
 tissues, cancer cell lines and in seven other related primates. Phylogenetic analysis of
 the HERV-S pol gene suggests division of the family into two groups among the
 tested species that have arisen throughout the primate evolution by gene duplication
 as well as other genetic alterations. Also, the tree analysis of human tissues and
 cancer cells suggest that expression of the chromosome X pol fragment is identical to
 expression of the pol fragment in cancerous cells more than its relation to the pol
 sequence on other human chromosomes. To sum up, our data provide a clarification
 about the dynamic evolutionary characteristics as well as phylogenetic relationships
 of HERV-S family pol gene in primates.
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