Abstract
Available complete genomic sequences of hemiascomycetous yeast species were analysed in order to identify the APSES protein family, which belongs to transcriptional factors of the basic helix-loop-helix (bHLH) class. Phylogenetic analyses of the amino acid sequences revealed that a similar set of proteins were present in all yeast species studied. The genome duplication event of Saccharomycetales allows the acquisition of complementary functions between the APSES proteins. Putative ancestors, such as Ashbya gossypii, the Kluyveromyces group and filamentous fungi, only have one APSES protein. Conserved gene order relationships allow the possibility of tracing the evolution of this family and the detection of duplication events. Multiple alignments revealed strict conservation of the APSES motif, although other regions of the APSES proteins were diversified. This review focuses on the evolution of the gene family of APSES proteins in related Hemiascomycetes species; the comparisons could shed light on the functional overlap of these proteins with regard to the regulation of morphogenetic processes and their involvement in the virulence of pathogenic microorganisms.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
