Abstract
Cortical evoked potentials (EP) provide localized data regarding brain function and may offer prognostic information and insights into the pathologic mechanisms of malaria-mediated cerebral injury. As part of a prospective cohort study, we obtained somatosensory evoked potentials (SSEPs) and brainstem auditory EPs (AEPs) within 24 hours of admission on 27 consecutive children admitted with cerebral malaria (CM). Children underwent follow-up for 12 months to determine if they had any long term neurologic sequelae. EPs were obtained in 27 pediatric CM admissions. Two children died. Among survivors followed an average of 514 days, 7/25 (28.0%) had at least one adverse neurologic outcome. Only a single subject had absent cortical EPs on admission and this child had a good neurologic outcome. Among pediatric CM survivors, cortical EPs are generally intact and do not predict adverse neurologic outcomes. Further study is needed to determine if alterations in cortical EPs can be used to predict a fatal outcome in CM.
Highlights
Materials and Methods external auditory canal for delivery of auditory stimulus
As part of a prospece tive cohort study, we obtained somatosensory evoked potentials (SSEPs) and brainstem m auditory EPs (AEPs) within 24 hours of admission on 27 consecutive children admitted with m cerebral malaria (CM)
The SSEPs are presynaptic and postsynaptic responses recorded over the limbs, spine and scalp following the stimulation of peripheral nerve trunks
Summary
A CM-specific retinopathy has recently been described that further enhances diagnostic certainty.[1,6,7,8,9] Of children with CM who reach. As part of a prospece tive cohort study, we obtained somatosensory evoked potentials (SSEPs) and brainstem m auditory EPs (AEPs) within 24 hours of admission on 27 consecutive children admitted with m cerebral malaria (CM). The SSEPs are presynaptic and postsynaptic responses recorded over the limbs, spine and scalp following the stimulation of peripheral nerve trunks (median and/or posterior tibial nerves) They provide a measure of sensory conduction and thereby detect lesions in proximal peripheral nerves, spinal cord, brainstem and the brain.[14] AEPs consist of auditory (click) stimuli delivered to each ear following which responses are recorded in the brainstem and cortex. AEPs were performed by inserting small ear buds into the
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