Evoked potential changes in patients with Parkinson's disease.

Chunyan Liu,Binda Wang,Bona Wang,Weiguo Tang,Songbin He,Yaping Zhang

doi:10.1002/brb3.703

Abstract

ObjectivePatients with Parkinson's disease (PD) may have sensory dysfunction, and it can be more easily demonstrated through electrophysiologic testing. We aimed to explore whether the impairment of brainstem visual and auditory passageway exists in PD patients using visual evoked potential (VEP) and brainstem auditory evoked potential (BAEP) examinations.MethodsForty‐two PD cases and thirty controls participated in the study. All subjects underwent the VEP and BAEP examinations. The N75, P100, N145 latencies and P100 amplitude of VEP, the latencies of waves I, III, V and the interpeak latencies (IPL) of waves I–III, III–V, I–V were measured.ResultsThe N75, P100, N145 latencies of VEP, but not the amplitude of P100, were significantly longer in patients with PD than the control group (p < .05). The latencies of wave III and wave V, the IPL of III–V and I–V were all significantly increased compared with control subjects while no significant difference was noted in waves I and I–III IPL.ConclusionOur results found that brainstem visual and auditory passageway may be impaired in PD patients.Significance VEP and BAEP can be served as sensitive measurements in helping prognosis and assessment the severity of the disease.

Highlights

Parkinson’s disease (PD) is a common degenerative disease of central nervous system among middle-aged populations
Our study explored whether the impairment of brainstem auditory and visual passageway exists in patients with PD using visual evoked potential (VEP) and brainstem auditory evoked potential (BAEP)
The P100 latency of VEP was positively correlated with the ages (r = .375, p = .014) (Table 4, Figure 5a), UPDRS score (r = .629, p < .001) (Table 4, Figure 5b), and H&Y classification (r = .597, p < .001) (Table 4, Figure 5c) while it did not show any relation between P100 latency with duration of disease and dopa dose (Table 4) in patients with PD

Summary

| INTRODUCTION

PD is a common degenerative disease of central nervous system among middle-aged populations. Our study explored whether the impairment of brainstem auditory and visual passageway exists in patients with PD using VEP and BAEP. It can imply the location of impairment was in the brainstem or the end organ and find its association with the clinical stage and severity of the disease. This was a case–control study developed between October 2015 and July 2016. Patients inclusion criteria were as follows: (1) without history of neurological disease or psychiatric disease; and (2) brain MRI showing normal image; patients exclusion criteria were as follows: (1) patients with dementia, severe anxiety, depression, psychosis, cerebrovascular illness, ophthalmologic, and auditory diseases; (2) secondary Parkinson’s syndrome; (3) and Other systematic diseases such as asthma, chronic obstructive pulmonary disease, heart failure, and cardiac arrhythmia

| Methods

| DISCUSSION

Findings

| CONCLUSION