Abstract
Substance P (SP) had no effect on cytosolic Ca 2+ concentration ([Ca 2+] i ) and inositol phosphate formation in mouse parotid and submandibular acinar cells, but induced a rapid increase in [Ca 2+] i and production of inositol phosphates in rat acinar cells. In addition, SP did not stimulate amylase release from mouse parotid acini, but SP-induced amylase release was seen in rats. These results indicate that the mouse lacks SP receptors on parotid and submandibular acinar cells.
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