Abstract
Helodermin, a newly isolated peptide from the venom of Gila monster ( Heloderma suspectum) was shown to stimulate the adenylate cyclase activity of rat pancreatic membranes as effectively as secretin and VIP. It also increased cyclic AMP levels and inhibited [ 125I]VIP binding in rat pancreatic acini. Finally, helodermin activated adenylate cyclase in membranes from rat heart, rat brain, and human heart, showing properties analogous yet distinct from those of secretin, VIP and PHI.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
