Abstract
The secretion of ATP from visualised varicosities on the surface of the mouse vas deferens was determined. Small diameter microelectrodes (about 6 μm and 20 μm) were placed over a set of 2 to 5 varicosities visualised with DiOC 2(5) in order to record excitatory junctional currents (c.j.c.s′) arising from the evoked secretion of quanta. In high external calcium concentrations, [Ca 2+] 0, the amplitude-frequency distribution of e.j.c.s′ was well described by binomial statistics in which binomial parameter n and the number of varicosities were approximately the same. Idazoxan (1 μM) had no effect on the e.j.c.s′ or the binomial parameters p and n. Suramin (100 μM) blocked the e.j.c.s′ as well as the spontaneous e.j.c.s′ (s.e.j.c.s′) in all cases. reducing n and p to zero. These results indicate that all varicosities secrete the transmitter blocked by suramin, presumably ATP.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
