Abstract
While indicated for schizophrenia and acute mania, ziprasidone’s evidence base and use in clinical practice extends beyond these regulatory approvals. We, an invited panel of experts led by a working group of 3, critically examined the evidence and our collective experience regarding the effectiveness, tolerability and safety of ziprasidone across its clinical uses. There was no opportunity for manufacturer input into the content of the review. As anticipated, ziprasidone was found to be effective for its indicated uses, although its utility in mania and mixed states lacked comparative data. Beyond these uses, the available data were either unimpressive or were lacking. An attractive characteristic is its neutral effect on weight thereby providing patients with a non-obesogenic long-term treatment option. Key challenges in practice include the need for dosing on a full stomach and managing its early onset adverse effect of restlessness. Addressing these issues are critical to its long-term success
Highlights
IntroductionAntipsychotic medications, including second generation agents (e.g. clozapine olanzapine, quetiapine, risperidone), have been prescribed more frequently, alone and in combination, and for an increasing breadth of indications in the last decade internationally [1,2,3]
Antipsychotic medications, including second generation agents, have been prescribed more frequently, alone and in combination, and for an increasing breadth of indications in the last decade internationally [1,2,3]
Clinicians should prioritize ziprasidone for patients with pre-existing metabolic issues, patients with metabolic adverse effects to other antipsychotics, and for patients wishing to mitigate the risk for metabolic adverse effects when considering their antipsychotic options
Summary
Antipsychotic medications, including second generation agents (e.g. clozapine olanzapine, quetiapine, risperidone), have been prescribed more frequently, alone and in combination, and for an increasing breadth of indications in the last decade internationally [1,2,3]. These medications are used to treat schizophrenia and related psychotic disorders, as well as other conditions including mood, anxiety, and behaviour disorders. With the availability of a variety of antipsychotics each with a unique mix of advantages and disadvantages, clinicians and patients navigate treatment choices to identify preferred options. The immediate and real challenge of working towards achieving agreed upon goals of therapy begins (e.g., reduction in symptoms, relapse prevention, recovery).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
