Abstract
The aim of this study was to examine whether the subthalamic nucleus (STN) plays a role in the transmission of PGO-like waves during REM sleep in humans. Simultaneous recordings from deep brain electrodes to record local field potentials (LFPs), and standard polysomnography to ascertain sleep/wake states. Main Hospital, department of clinical neurophysiology sleep laboratory. 12 individuals with Parkinson's disease, with electrodes implanted in the STN; and, as a control for localization purposes, 4 cluster headache patients with electrodes implanted in the posterior hypothalamus. All subjects underwent functional neurosurgery for implantation of deep brain stimulation electrodes. Sharp, polarity-reversed LFPs were recorded within the STN during REM sleep in humans. These subthalamic PGO-like waves (2-3 Hz, 80-200 pV, and 300-500 msec) appeared during REM epochs as singlets or in clusters of 3-13 waves. During the pre-REM period, subthalamic PGO-like waves were temporally related to drops in the submental electromyogram and/or onset of muscular atonia. Clusters of PGO-like waves occurred typically before and during the bursts of rapid eye movements and were associated with an enhancement in fast (15-35 Hz) subthalamic oscillatory activity. Subthalamic PGO-like waves can be recorded during pre-REM and REM sleep in humans. Our data suggest that the STN may play an active role in an ascending activating network implicated in the transmission of PGO waves during REM sleep in humans.
Highlights
The vast majority of evidence regarding the existence of PGO waves comes from experiments in cats, some
PGO waves have been shown to originate in the mesopontine tegmentum and the cholinergic neurons of the pedunculopontine tegmental nucleus (PPN), which is located at the junction between the mesencephalon and the pons, representing the final common path for their transfer to thalamocortical systems.[2,21]
Because the basal ganglia are in a position to gate the transfer of information from the PPN to the thalamus and forebrain, investigators have proposed that during REM sleep, these nuclei may participate in an ascending activating network involved in the rostral transmission of PGO waves.[18,29]
Summary
The vast majority of evidence regarding the existence of PGO waves comes from experiments in cats, some. Renewed interest in deep brain stimulation (DBS) has led to efforts to record neuronal activity, in the form of local field potentials (LFP), directly from the STN in human individuals with Parkinson’s disease following implantation of DBS electrodes.[30] Using simultaneous polysomnography (PSG) and DBS electrode recordings, the present study was designed to explore the participation of the STN in an ascending activating network involved in the transmission of PGO-like waves during REM sleep in humans
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