Abstract
The aim of this study was to characterize the solid state properties of (4E)-2-(1H-pyrazol-3-ylamino)-4-(1H-pyrazol-3-ylimino)naphthalen-1(4H)-one (BiPNQ), a compound with a significant inhibitory activity against Trypanosoma cruzi, the etiological agent of Chagas disease (American trypanosomiasis). Methods used included Differential Scanning Calorimetry (DSC), Thermogravimetry (TG), Fourier Transform Infrared Spectroscopy (FTIR), Powder X-Ray Diffraction (PXRD), Hot Stage, and Confocal Microscopy. Two BiPNQ samples were obtained by crystallization from absolute methanol and 2-propanol-water that exhibited different thermal behaviours, PXRD patterns, and FTIR spectra, indicating the existence of an anhydrous form (BiPNQ-I) and a solvate (BIPNQ-s), which on heating desolvated leading to the anhydrous modification BiPNQ-I. It was determined that FTIR, DSC, and PXRD are useful techniques for the characterization and identification of the crystalline modifications of BiPNQ.
Highlights
Many organic and inorganic compounds are able to exist in more than one crystalline form, a property known as polymorphism [1,2,3,4,5,6,7,8]
The relevance of this phenomenon in the pharmaceutical industry is that the different polymorphs of an active pharmaceutical ingredient (API) generally exhibit different melting points, X-ray powder patterns, solubility, and bioavailability, even though they are chemically equivalent [1,2,3,4,5,6,7,8]
Two solid samples of BiPNQ were obtained by crystallization experiments and were characterized by means of Differential Scanning Calorimetry (DSC), Termogravimetry (TG), Hot Stage and Confocal Microscopy, Fourier Transform Infrared Spectroscopy (FTIR), and Powder X-Ray Diffraction (PXRD) in order to evidence their
Summary
Many organic and inorganic compounds are able to exist in more than one crystalline form, a property known as polymorphism [1,2,3,4,5,6,7,8]. Two solid samples of BiPNQ were obtained by crystallization experiments and were characterized by means of Differential Scanning Calorimetry (DSC), Termogravimetry (TG), Hot Stage and Confocal Microscopy, Fourier Transform Infrared Spectroscopy (FTIR), and Powder X-Ray Diffraction (PXRD) in order to evidence their The product of desolvation of one of the prepared BiPNQ samples was identified by PXRD, and its DSC, TG, and FTIR profiles are presented.
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