Abstract
Forty-one benign and malignant ovarian tumors and 12 normal ovaries were studied immunologically, with extracts of gastric mucosa as reference, in the presence of antimucosa antisera, adult gastric antipepsinogens (anti Pg I–II, anti Pg III and anti Pg IV) and fetal gastric antipepsinogens (anti Pg IV). Pepsinogens were identified in 7 out of 24 benign tumors, all of the mucinous type and in 1 out of 17 malign tumors. Pepsinogen secretion did not occur in normal ovaries. The potentiality of pepsinogen synthesis by tumoral ovaries was the same as that of other antigens of the gastric or intestinal type as recently found in the same tumors. This potentiality did not seem to be linked to the malignancy of the tumors studied.
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