Abstract
BackgroundMature cystic teratomas are usually found in the ovaries. They are bilateral in 10 to 15% of cases and multiple cystic teratomas may be present in one ovary. The aim of this study is to clarify if development of mature cystic teratomas of the ovaries in a single host is metachronous or due to autoimplant or recurrence.Case presentationWe report a woman with bilateral mature cystic teratomas of the ovaries. DNA profiles of these teratomas were investigated via short tandem repeat (STR) analysis and methylation statuses were determined via methylation sensitive multiplex ligation-dependent probe amplification methods. The results showed that the cystic teratomas originated from different stages of oogonia or primary oocyte before germinal vesicle stage failure of meiosis I in female gametogenesis.Potentially relevant literature was searched in PubMed database. Cases of bilateral or multiple mature cystic teratomas of the ovaries were analyzed. To date, there has been no reported case of multiple mature cystic teratomas in which clarification of the origin was achieved using molecular genetic methods.ConclusionsThe results of this case study provide evidence of metachronous development of mature cystic teratomas of the ovaries and may serve as a reference in the management of patients following laparoscopic cystectomy.
Highlights
Mature cystic teratomas are usually found in the ovaries
Benign cystic teratomas of the ovary are composed of mature histologic structures of ectodermal, mesodermal and endodermal origin [4]
We investigated the Deoxyribonucleic acid (DNA) profiles of the teratomas using short tandem repeat (STR) analysis and methylation statuses using methylation sensitive multiplex ligation-dependent probe amplification methods
Summary
Mature cystic teratomas are usually found in the ovaries. They are bilateral in 10 to 15% of cases and multiple cystic teratomas may be present in one ovary. Case presentation: We report a woman with bilateral mature cystic teratomas of the ovaries. Cases of bilateral or multiple mature cystic teratomas of the ovaries were analyzed. Benign cystic teratomas (dermoid cysts) of the ovary are composed of mature histologic structures of ectodermal, mesodermal and endodermal origin [4]. They make up 10 to 15% of all ovarian tumors and tend to occur at relatively early age [5]. They are bilateral in 10 to 15% of cases and multiple cystic teratomas may be present in one ovary [6, 7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
