Abstract
Qbjectives. The aim of the study was to examine the associations between genetic variations in the human PAWR gene and major depressive disorder (MDD) as well as the response to antidepressant treatment. Methods. Six-hundred and two patients with MDD and 543 controls were included in the study; among the MDD patients, 268 were followed-up for a further 8 weeks in order to assess their response to treatment with selective serotonin reuptake inhibitors (SSRIs). Six polymorphisms (rs17005769, rs4842318, rs7305141, rs2307223, rs8176874 and rs2307220) of the PAWR gene were investigated with regard to their association with MDD and antidepressant treatment efficacy. Results. One polymorphism, rs8176874, was in genotypic (uncorrected P = 0.005) and allelic (uncorrected P = 0.0015) association with MDD. Several haplotypes spanning rs7305141–rs2307223–rs8176874 were also significantly associated with MDD after correction for multiple testing (corrected P < 0.05). However, neither single-marker nor haplotype-based analyses suggested an association between the studied markers and SSRI treatment response. Conclusions. Genetic variations in the PAWR gene are related to susceptibility to MDD but not to SSRI treatment response.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
