Evidence of evolving extraintestinal enteroaggregative Escherichia coli ST38 clone.

Marie Anne Chattaway,John Threlfall,Irene Rodríguez,Neil Woodford,Claire Jenkins,Michaela Day,Dik Mevius,Cindy Dierikx,Guanghui Wu,Beatriz Guerra,Kristina Kadlec,John Wain,Vivienne Donascimento,Reiner Helmuth,Martin J Woodward,Alieda Van Essen-Zandbergen,Holly Ciesielczuk,Martin J Day ,N G Coldham ,Anne‐Kathrin Schink ,Štefan Schwarz

doi:10.3201/eid2011.131845

Abstract

Evidence of evolving extraintestinal enteroaggregative Escherichia coli ST38 clone.

Highlights

The ability of diarrheagenic E. coli to cause extraintestinal infections has been shown in previous studies: a study among children in Nigeria linked enteroaggregative E. coli (EAEC) to uropathogenic clonal group A (2), and a study in Brazil showed that EAEC markers were present in 7.1% of the E. coli isolates from urinary tract infections (3)
We identified multidrug-resistant EAEC isolates belonging to ST38; the isolates had various somatic antigens and blaCTX-M genes (Table)
In the multilocus sequence types (MLSTs) public database, which contained 5,143 E. coli entries in June 2013, ST38 is predominantly associated with urinary tract infections, but in-house MLST studies at the Gastrointestinal Bacteria Reference Unit, Public Health England, have shown that ST38 is a successful EAEC group

Summary

Introduction

4. de Melo CB, de Sa MEP, Alves FF, McManus C, Aragão LF, Belo BB, et al Profile of international air passengers intercepted with illegal animal products in baggage at Guarulhos and Galeão airports in Brazil. The ability of diarrheagenic E. coli to cause extraintestinal infections has been shown in previous studies: a study among children in Nigeria linked EAEC to uropathogenic clonal group A (2), and a study in Brazil showed that EAEC markers were present in 7.1% of the E. coli isolates from urinary tract infections (3). Neither of these studies identified clonal lineages of EAEC associated with extraintestinal infections.

Results

Conclusion