Abstract
Purpose: Purpose: Synovial inflammation (synovitis) is considered to be an active process in the development and progression of OA joint pathology. Synovitis occurs at the onset of OA and is thought to contribute to the degradation of articular cartilage via the release of pro-inflammatory cytokines from synovial fibroblasts, which can induce the expression and release of cartilage matrixmetalloproteases and aggrecanases that degrade type II collagen and proteoglycans respectively. Importantly, we recently reported that synovial fibroblasts from end-stage obese OA patients display an enhanced inflammatory phenotype, compared to normal-weight OA patients.
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