Abstract
Bronchopulmonary cell populations enriched in alveolar macrophages were obtained by pulmonary lavage from guinea pigs exposed by inhalation to quartz dust. Extracts derived from disrupted bronchopulmonary cell populations in these animals were chemotactic for normal resident guinea pig alveolar macrophages. Similar chemoattractant activity was not, however, demonstrated in extracts of bronchopulmonary cell populations harvested from control (nondusted) guinea pigs. These quartz-induced, cell-associated chemotactic stimuli may account for the recruitment of mononuclear phagocytes into the lung during the evolution of silicotic lesions.
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