Abstract
The complexation between diclofenac sodium and β-cyclodextrin was investigatedin solution by 1D and 2D proton NMR. The continuous variation method was usedto establish the stoichiometry. The obtained results indicate that simultaneous inclusionof both rings occur giving rise to two isomeric 1:1 complexes. The view of abimodal binding between diclofenac sodium and β-cyclodextrin was also supportedby ROESY experiments. The association constants for the two 1:1 complexeswere calculated by non-linear least-squares regression analysis, applying an iterationprocedure. The geometry of the two 1:1 complexes, according to the obtainedNMR data is given.
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