Abstract
A chemiosmotic mechanism is the basis of ATP, Cl–-induced lysis of chromaffin granules, and we have now shown that the granule model successfully predicts the secretory properties of human platelets, bovine parathyroid cells, and bovine chromaffin cells. Like the granule lysis system, secretion from these cells requires specific anions in the medium, is inhibited by anion transport blocking drugs and proton ionophores, and is suppressed by elevated osmotic strength. We suggest that secretory granules fused to plasma membranes in secreting cells may experience net solute uptake and subsequently undergo local, outwardly directed osmotic lysis, or exocytosis.
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