Abstract
Pyrazinamide administration markedly impairs the uricosuric response to probenecid in man and in the chimpanzee (1,2). This effect of pyrazinamide on probenecid uricosuria has been attributed to inhibition of urate secretion by pyrazinamide and used as evidence for post secretory reabsorption of urate (1). However, other forms of drug interaction between probenecid and pyrazinamide have not been excluded. Recent evidence from studies in the chimpanzee and man suggest that urate and hippurate are secreted by different transport mechanisms (2,3). The present study was designed to further investigate the mechanism of pyrazinamide inhibition of the uricosuric response to probenecid in man and to compare the Interactions between pyrazinamide and probenecid with those between PAH and probenecid.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
