Evidence for two kinds of serotoninergic fibers in the ventral horn of spinal cord of the newly hatched chick

Abstract

We observed two types of serotonin-positive (5-HT) fibers in the ventral horn of the lumbar spinal cord of the newly hatched chicken: the first was composed of fine 5-HT fibers, which were increased transiently in the neuropil at 1 week after hatching (transient type); the second type consisted of thick fibers, which were densely localized around motoneuron somata in the motoneuron pools innervating extensor muscles of the hip joint (adult type). Pharmacological perturbation experiments demonstrated that these two types of 5-HT fibers may have different functions: the adult type of fibers may act to maintain an erect standing posture, whereas the transient type may act to induce or facilitate dendrogenesis (or dendritic elongation) of motoneurons. Thus, we concluded that 5-HT fibers may modulate neuronal transmission and serve as a kind of inductive agent for dendritic development in the chick spinal cord.