Abstract
SummaryThe IP or IV injection of 3 ml of plasma from hypoglycemic, hypophysecto-mized rats produced a lowering in hypophyse-al growth hormone (GH) on estimation 30 minutes later by the tibial epiphyseal cartilage test for GH. Plasma from untreated or hypoglycemic, intact rats and from untreated hypophysectomized rats was ineffective. No activity was found in plasma from hypogly-cemic, hypophysectomized rats with hypotha-lamic lesions in the ventral pre-mammillary area. The results are interpreted to mean that hypoglycemia results in the appearance of a circulating GH-releasing factor in the blood of hypophysectomized rats.
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