Abstract
The content of cytochrome P-450 in mastitic and healthy lactating bovine mammary gland was analyzed. Evidence for the existence of cytochrome P-450 in mastitic tissues was found. The amount of cytochrome P-450 formed in the assay ranged from 0.017 to 0.031 nmole/mg protein. The highest concentrations were found in severely inflamed samples, whereas and traces or no cytochrome P-450 were found in healthy tissues. The significance of cytochrome P-450 in mastitic mammary gland is discussed in relation to host defence involving oxidative killing of pathogens.
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