Abstract
The interaction between the spinal antinociceptive effects of selective μ or δ opioid agonists morphine and DSTBULET (Tyr- d-Ser(OtBu)-Gly-Phe-Leu-Thr), respectively, and the selective α 2 adrenergic agonist dexmedetomidine was examined on convergent dorsal horn neuronal responses in the intact anaesthetized rat. The coadministration of intrathecal morphine (0.5 μg, 2.5 μg) and dexmedetomidine (0.5 μg) produced a greater than additive inhibition of C fibre-evoked responses. Inhibitions were reversed by either the opioid antagonist naloxone or the α 2 adrenergic antagonist atipamezole. The coadministration of intrathecal DSTBULET (1 μg, 2.5 μg) and dexmedetomidine did not result in a supra-additive inhibition of C fibre-evoked responses. The results suggest that μ rather than δ opioid receptors are involved in the synergism of spinal opioid and α 2 adrenergic antinociception.
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