Evidence for the involvement of distinct voltage-sensitive calcium channels in the release of 3H-dopamine from primary cultures of mesencephalic neurons

Abstract

In ventral mesencephalic neurons cultured for five days the K +-evoked 3H-dopamine release is mediated through activation of N-type Ca 2+ channels, while L- or T-type channels appear to be inactive. In contrast, veratridine-elicited release of 3H-dopamine that was attenuated by tetrodotoxin was not altered by N-, L-, nor T-type Ca 2+ channel blockers.