Abstract
Based on reports elucidating sex differences in the prophylactic effects of aspirin against thromboembolism, sex and age differences in the activity of serum aspirin esterase (AE), the enzyme hydrolyzing aspirin, found predominantly in the liver, were measured in healthy persons of various age groups. In randomized healthy subjects, serum AE activity (μg of hydrolysed salicylic acid/30 min/ml) in females (average age 37.4±19.4, n=83) was significantly lower than in males (average age 40.2±18.2, n=81), While serum AE activity in males declined with increasing age, no age differences were found in females. Consequently, while men recorded higher activity than women in the younger age groups, the level of activity in men was lower than women in the older age groups. These sex and age differences in serum AE activity may be responsible in part for the sex differences in the efficacy of aspirin.
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